Testicular germ cell tumours

What changed: Testicular germ cell tumours

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Every dated change on the records linked to Testicular germ cell tumours, newest first: approvals and regulatory steps on its medicines, trials that reported, guideline versions, milestones, and when this page itself was checked. Dates come from the records; none is inferred. Orientation, not medical advice.

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September 2026 · 1

2026-09-08This recordTesticular germ cell tumours
Facts on this page last checked
When this page itself was last checked or edited.

2019 · 1

2019MilestoneTesticular germ cell tumours
miR-371a-3p validated as a serum marker (Dieckmann, JCO)
A milestone in how this cancer is treated.

2014 · 1

2014MilestoneTesticular germ cell tumours
Surveillance becomes standard for stage I
A milestone in how this cancer is treated.

2005 · 1

2005MilestoneCarboplatin
Carboplatin ×1 equals radiotherapy for stage I seminoma (MRC TE19)
A milestone in how this cancer is treated.

1997 · 1

1997MilestoneTesticular germ cell tumours
IGCCCG prognostic classification
Updated in 2021 with LDH and age refinements.

1989 · 1

1989MilestoneTesticular germ cell tumours
BEP ×3 sufficient for good-risk disease (Einhorn)
A milestone in how this cancer is treated.

1988 · 1

1988ApprovalIfosfamide
Ifosfamide approved in US
Germ cell testicular cancer; widely used off-label in sarcoma

1987 · 1

1987MilestoneEtoposide
BEP replaces PVB (Williams, NEJM)
Etoposide substitutes vinblastine with better efficacy and less neurotoxicity.

1983 · 1

1983ApprovalEtoposide
Etoposide approved in US
Refractory testicular tumours; small-cell lung cancer (1986)

1978 · 1

1978ApprovalCisplatin
Cisplatin approved in US
Testicular and ovarian cancer; bladder cancer 1993

1974 · 1

1974MilestoneCisplatin
Einhorn introduces cisplatin (PVB)
Cure rates in metastatic disease jump from ~10% to ~60-70%.

1973 · 1

1973ApprovalBleomycin
Bleomycin approved in US
Squamous cell carcinomas, Hodgkin and non-Hodgkin lymphoma, testicular carcinoma, malignant pleural effusion

1970 · 1

1970ApprovalPlicamycin
Plicamycin approved in US
Disseminated testicular tumours; hypercalcaemia and hypercalciuria of malignancy

1965 · 1

1965ApprovalVinblastine
Vinblastine approved in US
Hodgkin lymphoma, testicular cancer, Kaposi sarcoma, choriocarcinoma, breast cancer and others

1964 · 1

1964ApprovalDactinomycin (actinomycin D)
Dactinomycin (actinomycin D) approved in US
Wilms tumour, rhabdomyosarcoma, Ewing sarcoma, gestational trophoblastic neoplasia, metastatic testicular cancer, regional perfusion for sarcoma

1960 · 1

1960MilestoneMethotrexate
Li and colleagues: actinomycin D, methotrexate and chlorambucil active in GCT
A milestone in how this cancer is treated.