DDX10
DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression. Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 11q22.3 (HGNC).
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"DDX10" OR ABSTRACT:"DDX10" OR TITLE:"DEAD-box helicase 10" OR ABSTRACT:"DEAD-box helicase 10" OR TITLE:"Probable ATP-dependent RNA helicase DDX10" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX10" OR TITLE:"HRH-J8" OR ABSTRACT:"HRH-J8" OR TITLE:"Dbp4" OR ABSTRACT:"Dbp4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX10, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ddx10.json. Licence CC BY-NC 4.0.