DDX10
DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer.
Overview
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.87, animal model 0.31, genetic association 0.04, somatic mutation 0.98).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer.
- 1 · What it is
DDX10 (Probable ATP-dependent RNA helicase DDX10) is an enzyme. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Skin cancer.
- 2 · What goes wrong in cancer
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level.
- 3 · How drugs use it
No product in this corpus aims at DDX10 yet. Inhibitors are shaped to fit the enzyme's active site so the reaction the cancer relies on stops.
External identifiers
Sources: HGNC HGNC:2735 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q13206 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000178105 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: skin cancer 0.51, breast cancer 0.54 (GraphQL API, CC0))
Biology
Putative ATP-dependent RNA helicase that plays various role in innate immunity or inflammation. Plays a role in the enhancement of AIM2-induced inflammasome activation by interacting with AIM2 and stabilising its protein level. Negatively regulates viral infection by promoting interferon beta production and interferon stimulated genes/ISGs expression. Location: Cytoplasm; Nucleus; Nucleus, nucleolus (UniProt). Locus 11q22.3 (HGNC).
- Breast cancer: Open Targets association 0.54 with breast cancer (MONDO_0007254)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"DDX10" OR ABSTRACT:"DDX10" OR TITLE:"DEAD-box helicase 10" OR ABSTRACT:"DEAD-box helicase 10" OR TITLE:"Probable ATP-dependent RNA helicase DDX10" OR ABSTRACT:"Probable ATP-dependent RNA helicase DDX10" OR TITLE:"HRH-J8" OR ABSTRACT:"HRH-J8" OR TITLE:"Dbp4" OR ABSTRACT:"Dbp4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DDX10, not a curated reading list.