DGCR8
DGCR8 (Microprocessor complex subunit DGCR8) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver and a tumour suppressor, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Mesothelioma, Thyroid cancer, Diffuse large B-cell lymphoma and 3 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs. The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding. Specifically recognises and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing. Location: Nucleus; Nucleus, nucleolus (UniProt). Locus 22q11.21 (HGNC).
- Mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Diffuse large B-cell lymphoma: IntOGen driver in 1 cohort (DLBCLNOS)
- Pleural mesothelioma: IntOGen driver in 1 cohort (PLMESO)
- Papillary thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Wilms tumour: IntOGen driver in 1 cohort (WT)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"DGCR8" OR ABSTRACT:"DGCR8" OR TITLE:"DGCR8 microprocessor complex subunit" OR ABSTRACT:"DGCR8 microprocessor complex subunit" OR TITLE:"Microprocessor complex subunit DGCR8" OR ABSTRACT:"Microprocessor complex subunit DGCR8" OR TITLE:"DGCRK6" OR ABSTRACT:"DGCRK6" OR TITLE:"Gy1" OR ABSTRACT:"Gy1" OR TITLE:"pasha" OR ABSTRACT:"pasha") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DGCR8, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/dgcr8.json. Licence CC BY-NC 4.0.