FAS (Tumour necrosis factor receptor superfamily member 6) is a gene whose normal job is to hold cell growth in check. The public catalogues list it as an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Non-Hodgkin lymphoma, Leukaemia, Cervical cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase CASP8 to the activated receptor. The resulting death-inducing signalling complex (DISC) performs CASP8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). Location: Cell membrane; Membrane raft; Secreted (UniProt). Locus 10q23.31 (HGNC).
- Non-Hodgkin lymphoma: Open Targets association 0.71 with non-Hodgkin lymphoma (MONDO_0018908); IntOGen driver in 1 cohort (MLYM)
- Leukaemia: Open Targets association 0.63 with leukaemia (MONDO_0005059)
- Cervical cancer: IntOGen driver in 1 cohort (CESC)
- Skin cancer: Open Targets association 0.52 with skin cancer (MONDO_0002898)
- Diffuse large B-cell lymphoma: Open Targets association 0.59 with diffuse large B-cell lymphoma (MONDO_0018905); CIViC evidence names this disease
- Melanoma: Open Targets association 0.52 with melanoma (MONDO_0005105)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"FAS" OR ABSTRACT:"FAS" OR TITLE:"Fas cell surface death receptor" OR ABSTRACT:"Fas cell surface death receptor" OR TITLE:"Tumor necrosis factor receptor superfamily member 6" OR ABSTRACT:"Tumor necrosis factor receptor superfamily member 6" OR TITLE:"CD95" OR ABSTRACT:"CD95" OR TITLE:"APO-1" OR ABSTRACT:"APO-1" OR TITLE:"FAS1" OR ABSTRACT:"FAS1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FAS, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/fas.json. Licence CC BY-NC 4.0.