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GPR65 is a sensor on immune cells that detects acidity. Tumours are often acidic, and the idea behind blocking GPR65 is to stop that acidity from turning nearby immune cells into ones that help the tumour; a GPR65 inhibitor is in an early trial. This dossier gathers the 1 product (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Proton-sensing receptor (also called TDAG8) that signals through G(s) and cyclic AMP; it may also bind the glycosphingolipid psychosine (UniProt Q8IYL9).
| Modality | Phase 1 |
|---|---|
| Small molecule 1 |
No trial in the corpus names this target or one of its products.
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"GPR65" OR ABSTRACT:"GPR65" OR TITLE:"G protein-coupled receptor 65" OR ABSTRACT:"G protein-coupled receptor 65" OR TITLE:"TDAG8" OR ABSTRACT:"TDAG8") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GPR65, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/gpr65.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/gpr65.json. Licence CC BY-NC 4.0.