Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2)
The four mismatch repair proteins proofread newly copied DNA; when a tumour loses one of them its DNA fills with small errors, and that state (dMMR or MSI-high) is what lets immunotherapy work across many cancers. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Deficient repair raises the mutation rate a hundredfold and produces frameshift neoantigens in repeat-containing genes, which is the mechanistic basis for checkpoint inhibitor sensitivity.
- Colorectal cancer (about 15 percent, most sporadic through MLH1 methylation)
- Endometrial cancer (about 25 to 30 percent)
- Gastric, small bowel, urothelial and other Lynch-spectrum tumours
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"Mismatch repair proteins" OR ABSTRACT:"Mismatch repair proteins" OR TITLE:"MLH1, MSH2, MSH6, PMS2" OR ABSTRACT:"MLH1, MSH2, MSH6, PMS2" OR TITLE:"MLH1" OR ABSTRACT:"MLH1" OR TITLE:"MSH2" OR ABSTRACT:"MSH2" OR TITLE:"MSH6" OR ABSTRACT:"MSH6" OR TITLE:"PMS2" OR ABSTRACT:"PMS2") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Mismatch repair proteins (MLH1, MSH2, MSH6, PMS2), not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/mmr.json. Licence CC BY-NC 4.0.