MN1 (Transcriptional activator MN1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Colorectal cancer, Skin cancer and 1 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull. May play a role in tumour suppression. Location: Nucleus (UniProt). Locus 22q12.1 (HGNC).
- Breast cancer: Open Targets association 0.60 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
- Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"MN1" OR ABSTRACT:"MN1" OR TITLE:"MN1 proto-oncogene, transcriptional regulator" OR ABSTRACT:"MN1 proto-oncogene, transcriptional regulator" OR TITLE:"Transcriptional activator MN1" OR ABSTRACT:"Transcriptional activator MN1" OR TITLE:"MGCR1-PEN" OR ABSTRACT:"MGCR1-PEN" OR TITLE:"MGCR1" OR ABSTRACT:"MGCR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MN1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/mn1.json. Licence CC BY-NC 4.0.