MN1
MN1 (Transcriptional activator MN1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Colorectal cancer, Skin cancer and 1 more.
Overview
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL.
CIViC holds 3 clinical evidence items and 2 assertions across 1 variant. Open Targets scores its association with cancer at 0.71 (direct and indirect evidence; datatypes literature 0.95, animal model 0.45, genetic association 0.52, somatic mutation 0.82).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · MN1 (Transcriptional activator MN1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Colorectal cancer, Skin cancer and 1 more.
- 1 · What it is
MN1 (Transcriptional activator MN1) is a protein that switches other genes on and off. The public catalogues list it as a biomarker and a fusion partner, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Breast cancer, Colorectal cancer, Skin cancer and 1 more.
- 2 · What goes wrong in cancer
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves.
- 3 · How drugs use it
No product in this corpus aims at MN1 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7180 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q10571 (protein name, function text, keywords and locations (REST API)); CIViC gene MN1 (3 evidence items, 2 assertions, 1 variants; diseases: Astroblastoma, MN1-altered (GraphQL API, CC0)); Open Targets ENSG00000169184 (association with cancer (MONDO_0004992) 0.71; per-cancer scores at or above 0.5: colorectal cancer 0.52, melanoma 0.51, skin cancer 0.51, breast cancer 0.60 (GraphQL API, CC0))
Biology
Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull. May play a role in tumour suppression. Location: Nucleus (UniProt). Locus 22q12.1 (HGNC).
- Breast cancer: Open Targets association 0.60 with breast cancer (MONDO_0007254)
- Colorectal cancer: Open Targets association 0.52 with colorectal cancer (MONDO_0005575)
- Skin cancer: Open Targets association 0.51 with skin cancer (MONDO_0002898)
- Melanoma: Open Targets association 0.51 with melanoma (MONDO_0005105)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: CIViC holds 3 clinical evidence items on its variants; UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "clinical-evidence" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
- Diseases the sources name that have no OnCo cancer page yet, so they are not linked: Astroblastoma, MN1-altered.
Latest papers
topQuery for this target: (TITLE:"MN1" OR ABSTRACT:"MN1" OR TITLE:"MN1 proto-oncogene, transcriptional regulator" OR ABSTRACT:"MN1 proto-oncogene, transcriptional regulator" OR TITLE:"Transcriptional activator MN1" OR ABSTRACT:"Transcriptional activator MN1" OR TITLE:"MGCR1-PEN" OR ABSTRACT:"MGCR1-PEN" OR TITLE:"MGCR1" OR ABSTRACT:"MGCR1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about MN1, not a curated reading list.