NFIB (Nuclear factor 1 B-type) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Oral cavity cancer and Adenoid cystic carcinoma. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Location: Nucleus (UniProt). Locus 9p23-p22.3 (HGNC).
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
- Oral cavity cancer: Open Targets association 0.55 with oral cavity cancer (MONDO_0005515)
- Adenoid cystic carcinoma: Open Targets association 0.52 with adenoid cystic carcinoma (MONDO_0004971)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"NFIB" OR ABSTRACT:"NFIB" OR TITLE:"nuclear factor I B" OR ABSTRACT:"nuclear factor I B" OR TITLE:"Nuclear factor 1 B-type" OR ABSTRACT:"Nuclear factor 1 B-type" OR TITLE:"NFI-RED" OR ABSTRACT:"NFI-RED" OR TITLE:"NFIB2" OR ABSTRACT:"NFIB2" OR TITLE:"NFIB3" OR ABSTRACT:"NFIB3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NFIB, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/nfib.json. Licence CC BY-NC 4.0.