NFIB
NFIB (Nuclear factor 1 B-type) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Oral cavity cancer and Adenoid cystic carcinoma.
Overview
Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication.
Open Targets scores its association with cancer at 0.67 (direct and indirect evidence; datatypes affected pathway 0.31, literature 0.98, genetic association 0.35, somatic mutation 0.94, animal model 0.85).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · NFIB (Nuclear factor 1 B-type) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Oral cavity cancer and Adenoid cystic carcinoma.
- 1 · What it is
NFIB (Nuclear factor 1 B-type) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer, Oral cavity cancer and Adenoid cystic carcinoma.
- 2 · What goes wrong in cancer
Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2.
- 3 · How drugs use it
No product in this corpus aims at NFIB yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:7785 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt O00712 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000147862 (association with cancer (MONDO_0004992) 0.67; per-cancer scores at or above 0.5: breast cancer 0.52, oral cavity cancer 0.55, adenoid cystic carcinoma 0.52 (GraphQL API, CC0))
Biology
Transcriptional activator of GFAP, essential for proper brain development. Recognises and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. Location: Nucleus (UniProt). Locus 9p23-p22.3 (HGNC).
- Breast cancer: Open Targets association 0.52 with breast cancer (MONDO_0007254)
- Oral cavity cancer: Open Targets association 0.55 with oral cavity cancer (MONDO_0005515)
- Adenoid cystic carcinoma: Open Targets association 0.52 with adenoid cystic carcinoma (MONDO_0004971)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"NFIB" OR ABSTRACT:"NFIB" OR TITLE:"nuclear factor I B" OR ABSTRACT:"nuclear factor I B" OR TITLE:"Nuclear factor 1 B-type" OR ABSTRACT:"Nuclear factor 1 B-type" OR TITLE:"NFI-RED" OR ABSTRACT:"NFI-RED" OR TITLE:"NFIB2" OR ABSTRACT:"NFIB2" OR TITLE:"NFIB3" OR ABSTRACT:"NFIB3") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about NFIB, not a curated reading list.
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