CHCHD7
CHCHD7 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 7) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
Overview
UniProt has no function text for Q9BUK0; HGNC names it "coiled-coil-helix-coiled-coil-helix domain containing 7".
Open Targets scores its association with cancer at 0.56 (direct and indirect evidence; datatypes literature 0.10, genetic association 0.09, somatic mutation 0.89).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CHCHD7 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 7) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
- 1 · What it is
CHCHD7 (Coiled-coil-helix-coiled-coil-helix domain-containing protein 7) is a gene. The public catalogues list it as a fusion partner, and the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
- 2 · What goes wrong in cancer
UniProt has no function text for Q9BUK0; HGNC names it "coiled-coil-helix-coiled-coil-helix domain containing 7". Location: Mitochondrion intermembrane space (UniProt).
- 3 · How drugs use it
No product in this corpus aims at CHCHD7 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:28314 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9BUK0 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000170791 (association with cancer (MONDO_0004992) 0.56; per-cancer scores at or above 0.5: oral cavity cancer 0.51 (GraphQL API, CC0))
Biology
UniProt has no function text for Q9BUK0; HGNC names it "coiled-coil-helix-coiled-coil-helix domain containing 7". Location: Mitochondrion intermembrane space (UniProt). Locus 8q12.1 (HGNC).
- Oral cavity cancer: Open Targets association 0.51 with oral cavity cancer (MONDO_0005515)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: UniProt disease notes describe a translocation or gene fusion involving the gene. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CHCHD7" OR ABSTRACT:"CHCHD7" OR TITLE:"coiled-coil-helix-coiled-coil-helix domain containing 7" OR ABSTRACT:"coiled-coil-helix-coiled-coil-helix domain containing 7" OR TITLE:"Coiled-coil-helix-coiled-coil-helix domain-containing protein 7" OR ABSTRACT:"Coiled-coil-helix-coiled-coil-helix domain-containing protein 7" OR TITLE:"MGC2217" OR ABSTRACT:"MGC2217" OR TITLE:"COX23" OR ABSTRACT:"COX23") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CHCHD7, not a curated reading list.
Similar pages
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