WIF1
WIF1 (Wnt inhibitory factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
Overview
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
Open Targets scores its association with cancer at 0.63 (direct and indirect evidence; datatypes literature 0.97, genetic association 0.19, somatic mutation 0.97).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · WIF1 (Wnt inhibitory factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
- 1 · What it is
WIF1 (Wnt inhibitory factor 1) is a gene. In the public catalogues the evidence so far is association rather than a proven role. Tied to Breast cancer and Oral cavity cancer.
- 2 · What goes wrong in cancer
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation.
- 3 · How drugs use it
No product in this corpus aims at WIF1 yet. Drugs bind the molecule precisely: to switch it off, flag the cell for the immune system, or deliver a payload.
External identifiers
Sources: HGNC HGNC:18081 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q9Y5W5 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000156076 (association with cancer (MONDO_0004992) 0.63; per-cancer scores at or above 0.5: breast cancer 0.55, oral cavity cancer 0.51 (GraphQL API, CC0))
Biology
Binds to WNT proteins and inhibits their activities. May be involved in mesoderm segmentation. Location: Secreted (UniProt). Locus 12q14.3 (HGNC).
- Breast cancer: Open Targets association 0.55 with breast cancer (MONDO_0007254)
- Oral cavity cancer: Open Targets association 0.51 with oral cavity cancer (MONDO_0005515)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"WIF1" OR ABSTRACT:"WIF1" OR TITLE:"Wnt inhibitory factor 1" OR ABSTRACT:"Wnt inhibitory factor 1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about WIF1, not a curated reading list.
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