CRTC3
CRTC3 (CREB-regulated transcription coactivator 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
Overview
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4.
Open Targets scores its association with cancer at 0.64 (direct and indirect evidence; datatypes literature 0.68, genetic association 0.31, somatic mutation 0.78).
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · CRTC3 (CREB-regulated transcription coactivator 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
- 1 · What it is
CRTC3 (CREB-regulated transcription coactivator 3) is a protein that switches other genes on and off. In the public catalogues the evidence so far is association rather than a proven role. Tied to Oral cavity cancer.
- 2 · What goes wrong in cancer
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites.
- 3 · How drugs use it
No product in this corpus aims at CRTC3 yet. Transcription factors have no pocket to plug, so drugs either degrade them or block the partner protein they need to dock on DNA.
External identifiers
Sources: HGNC HGNC:26148 (approved symbol, name, aliases, locus and cross-references (hgnc_complete_set.txt)); UniProt Q6UUV7 (protein name, function text, keywords and locations (REST API)); Open Targets ENSG00000140577 (association with cancer (MONDO_0004992) 0.64; per-cancer scores at or above 0.5: oral cavity cancer 0.53 (GraphQL API, CC0))
Biology
Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signalling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukaemia virus type 1 (HTLV-1) long terminal repeats (LTR). Location: Nucleus; Cytoplasm (UniProt). Locus 15q26.1 (HGNC).
- Oral cavity cancer: Open Targets association 0.53 with oral cavity cancer (MONDO_0005515)
Notes
top- Written by scripts/fetch-cancer-genes.ts from CIViC, Open Targets, IntOGen, HGNC and UniProt; the function text is UniProt's, condensed and in UK spelling. Roles: none stated by the sources. Evidence tier "association-only" is the strongest of those signals.
- Prevalence not recorded: none of the sources gives a positivity rate.
Latest papers
topQuery for this target: (TITLE:"CRTC3" OR ABSTRACT:"CRTC3" OR TITLE:"CREB regulated transcription coactivator 3" OR ABSTRACT:"CREB regulated transcription coactivator 3" OR TITLE:"CREB-regulated transcription coactivator 3" OR ABSTRACT:"CREB-regulated transcription coactivator 3" OR TITLE:"FLJ21868" OR ABSTRACT:"FLJ21868") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CRTC3, not a curated reading list.
Similar pages
not linked directly; found by shared links- TargetCHCHD7
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
- TargetTCEA1
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
- TargetHMGA2
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
- TargetWIF1
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
- TargetPLAG1
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
- TargetNFIB
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
- TargetMYB
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.
- TargetMAML2
Shares Oral cavity cancer (mouth and tongue), Open Targets Platform.