PABPC1
PABPC1 (Polyadenylate-binding protein 1) is a gene that drives cell growth when it is altered. The public catalogues list it as an oncogene driver, and it is called a cancer driver by mutation analysis of patient cohorts. Tied to Hepatocellular carcinoma, Multiple myeloma, Bladder & urothelial cancer and 5 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Binds the poly(A) tail of mRNA, including that of its own transcript, and regulates processes of mRNA metabolism such as pre-mRNA splicing and mRNA stability. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Binds to N6-methyladenosine (m6A)-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Location: Cytoplasm; Cytoplasm, Stress granule; Nucleus; Cell projection, lamellipodium (UniProt). Locus 8q22.3 (HGNC).
- Hepatocellular carcinoma: IntOGen driver in 1 cohort (HCC)
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
- Bladder & urothelial cancer: IntOGen driver in 1 cohort (UTUC)
- Thyroid cancer: IntOGen driver in 1 cohort (WDTC)
- Diffuse large B-cell lymphoma: IntOGen driver in 2 cohorts (DLBCLNOS)
- Basal cell carcinoma: IntOGen driver in 1 cohort (BCC)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"PABPC1" OR ABSTRACT:"PABPC1" OR TITLE:"poly A binding protein cytoplasmic 1" OR ABSTRACT:"poly A binding protein cytoplasmic 1" OR TITLE:"Polyadenylate-binding protein 1" OR ABSTRACT:"Polyadenylate-binding protein 1" OR TITLE:"PABP1" OR ABSTRACT:"PABP1" OR TITLE:"PABPL1" OR ABSTRACT:"PABPL1" OR TITLE:"PAB1" OR ABSTRACT:"PAB1") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about PABPC1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/pabpc1.json. Licence CC BY-NC 4.0.