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RIPK2 relays alarm signals from the NOD1 and NOD2 sensors that detect bacteria, switching on inflammation. It has been proposed as a cancer target both for its effects on immune cells and, in prostate cancer, for helping tumours spread; a RIPK2 inhibitor is in an early melanoma trial. This dossier gathers the 1 product (0 approved), 1 trial, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Serine/threonine/tyrosine kinase recruited to NOD1 and NOD2 through CARD-CARD interaction; it forms filaments and is polyubiquitinated by XIAP, BIRC2, BIRC3 and LUBAC, becoming a scaffold for downstream signalling (UniProt O43353).
| Modality | Phase 1 |
|---|---|
| Small molecule 1 |
| Trial | Setting | Result | Products | ||
|---|---|---|---|---|---|
| 1/2 | Planned | REVERT Study: A Phase 1b/2a Study to Assess the Safety and Efficacy of OPM-101 Combined With Anti-PD-1 in Patients With Advanced Melanoma Showing Resistance to Anti-PD-1 | - |
No recorded escape route names this target.
No pathway diagram carries this target as a node.
No companion diagnostic in the registry measures this target.
No model entry for this target yet; check the cancer entries on the models page.
No open questions recorded for this target yet. Suggest one.
Query for this target: (TITLE:"RIPK2" OR ABSTRACT:"RIPK2" OR TITLE:"receptor interacting serine/threonine kinase 2" OR ABSTRACT:"receptor interacting serine/threonine kinase 2" OR TITLE:"RIP2" OR ABSTRACT:"RIP2" OR TITLE:"RICK" OR ABSTRACT:"RICK") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about RIPK2, not a curated reading list.
The dossier as machine-readable JSON, at /api/v1/dossiers/ripk2.json: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/ripk2.json. Licence CC BY-NC 4.0.