ZEB1 (Zinc finger E-box-binding homeobox 1) is a protein that switches other genes on and off. The public catalogues list it as a drug target, an oncogene driver, a tumour suppressor and a biomarker, and clinical evidence ties its variants to diagnosis, prognosis or drug response. Tied to Colorectal cancer, Nasopharyngeal carcinoma, Multiple myeloma and 4 more. This dossier gathers the 0 products (0 approved), 0 trials, 0 pathways and 0 resistance routes in the corpus that involve it, with external identifiers so it can be joined to UniProt, ChEMBL, Open Targets and the rest of biology.
Biology
Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Location: Nucleus (UniProt). Locus 10p11.22 (HGNC).
- Colorectal cancer: CIViC evidence names this disease
- Nasopharyngeal carcinoma: IntOGen driver in 1 cohort (NPC)
- Multiple myeloma: IntOGen driver in 1 cohort (PCM)
- Mantle cell lymphoma: CIViC evidence names this disease
- Non-small-cell lung cancer: IntOGen driver in 2 cohorts (LUAD, LUSC)
- Glioma & glioblastoma: IntOGen driver in 1 cohort (GBM)
External identifiers
Built from HGNC, Ensembl, UniProt and ChEMBL idsProducts by modality and phase
Browse products →No product in the corpus is aimed at this target yet.
Trials
Evidence ranking →No trial in the corpus names this target or one of its products.
Resistance routes
Unaddressed routes →The resistance atlas has no route that names this target.
Pathways
Pathway-to-drug matrix →No pathway diagram carries this target as a node.
Companion diagnostics
Assay registry →No companion diagnostic in the registry measures this target.
Preclinical models
All models →No model entry for this target yet; check the cancer entries on the models page.
Open questions
All open questions →No open questions recorded for this target yet. Suggest one.
Literature
Preprints →Query for this target: (TITLE:"ZEB1" OR ABSTRACT:"ZEB1" OR TITLE:"zinc finger E-box binding homeobox 1" OR ABSTRACT:"zinc finger E-box binding homeobox 1" OR TITLE:"Zinc finger E-box-binding homeobox 1" OR ABSTRACT:"Zinc finger E-box-binding homeobox 1" OR TITLE:"AREB6" OR ABSTRACT:"AREB6" OR TITLE:"NIL-2-A" OR ABSTRACT:"NIL-2-A" OR TITLE:"Zfhep" OR ABSTRACT:"Zfhep") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ZEB1, not a curated reading list.
Export
The dossier as machine-readable JSON: identifiers from HGNC, Ensembl, UniProt and ChEMBL, products with status, trials, pathways, hotspots, open questions and assays. The full entity record is in the open API at /api/v1/entities/zeb1.json. Licence CC BY-NC 4.0.