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AST-001 is an experimental small molecule AKR1C3-activated prodrug from Ascentawits Pharmaceuticals, in phase 1 trials for pancreatic cancer and advanced solid tumours.
AST-001 is a small molecule AKR1C3-activated prodrug ('small molecule targeted conjugate') from Ascentawits Pharmaceuticals. A first-in-class small-molecule prodrug from the company's AKR1C3 enzyme-activated prodrug platform, designed to kill tumour cells that overexpress AKR1C3 while sparing normal cells. Its furthest stage is phase 1, for pancreatic cancer and advanced solid tumours. ClinicalTrials.gov registers it in one study linked below. Company release (12 Nov 2024, republished by pharnexcloud): first-in-human phase 1 in China completed, first patient dosed 7 July 2022. Registry NCT06245330 (phase 1/2, pancreatic cancer and solid tumours) recruiting. Whether it works in people has not been established unless a trial below reports it.
A first-in-class small-molecule prodrug from the company's AKR1C3 enzyme-activated prodrug platform, designed to kill tumour cells that overexpress AKR1C3 while sparing normal cells. Connects to AKR1C3.
1.AST-001 slips into a pocket on AKR1C3.
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Query for this drug: (TITLE:"AST-001" OR ABSTRACT:"AST-001") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about AST-001, not a curated reading list.
Shares Ascentawits Pharmaceuticals, Metastatic cancer (cancer that has spread), Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares AKR1C3, Ascentawits Pharmaceuticals, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Ascentawits Pharmaceuticals and the tag pipeline.
Shares Ascentawits Pharmaceuticals and the tag pipeline.
Shares Metastatic cancer (cancer that has spread), Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Metastatic cancer (cancer that has spread), Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Metastatic cancer (cancer that has spread), Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Metastatic cancer (cancer that has spread), Pancreatic ductal adenocarcinoma and the tag pipeline.
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