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Belzupacap sarotalocan is an experimental virus-like drug conjugate from Aura Biosciences, in phase 3 trials for choroidal melanoma, metastases to the choroid and ocular surface tumours and other cancers.
Belzupacap sarotalocan (AU-011, bel-sar) is a virus-like drug conjugate (light-activated) from Aura Biosciences. A virus-like particle joined to a light-sensitive dye. When an ophthalmic laser shines 689 nm infrared light on the tumour, it releases reactive oxygen species that kill tumour cells, and this is followed by an anti-tumour immune response. Its furthest stage is phase 3, for choroidal melanoma (early, and indeterminate lesions), metastases to the choroid, ocular surface tumours and non-muscle-invasive bladder cancer. ClinicalTrials.gov registers it in 5 studies linked below. Global phase 3 CoMpass (NCT06007690) in early choroidal melanoma, active not recruiting; phase 2 in metastases to the choroid (NCT06643884) recruiting; phase 1 in non-muscle-invasive bladder cancer (NCT05483868) active not recruiting; first-in-human study in ocular surface tumours per company site. Whether it works in people has not been established unless a trial below reports it.
A virus-like particle joined to a light-sensitive dye. When an ophthalmic laser shines 689 nm infrared light on the tumour, it releases reactive oxygen species that kill tumour cells, and this is followed by an anti-tumour immune response.
1.Belzupacap sarotalocan's antibody arm binds its target on the surface of the cancer cell.
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Query for this drug: (TITLE:"Belzupacap sarotalocan" OR ABSTRACT:"Belzupacap sarotalocan" OR TITLE:"AU-011" OR ABSTRACT:"AU-011" OR TITLE:"bel-sar" OR ABSTRACT:"bel-sar") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Belzupacap sarotalocan, not a curated reading list.
Shares Non-muscle-invasive bladder cancer and the tag pipeline.
Shares Uveal melanoma and the tag pipeline.
Shares Non-muscle-invasive bladder cancer and the tag pipeline.
Shares Non-muscle-invasive bladder cancer and the tag pipeline.
Shares Non-muscle-invasive bladder cancer and the tag pipeline.
Shares Non-muscle-invasive bladder cancer and the tag pipeline.
Shares Non-muscle-invasive bladder cancer and the tag pipeline.
Shares Non-muscle-invasive bladder cancer and the tag pipeline.
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