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CFI-402257 is an experimental small molecule from Treadwell Therapeutics, in phase 2 trials for HR-positive / HER2-negative breast cancer, HER2-negative breast cancer and advanced solid tumours.
CFI-402257 is a small molecule from Treadwell Therapeutics. A potent and selective small-molecule inhibitor of TTK, tested alone in solid tumours and with fulvestrant or paclitaxel in breast cancer. Its furthest stage is phase 2, for HR-positive / HER2-negative breast cancer, HER2-negative breast cancer and advanced solid tumours. ClinicalTrials.gov registers it in 4 studies linked below. NCT05251714 (Treadwell, phase 1/2) and NCT03568422 (CCTG IND.236) active, not recruiting; NCT05601440 (CCTG platform, phase 2) recruiting (registry, checked 3 Nov 2026). Whether it works in people has not been established unless a trial below reports it.
A potent and selective small-molecule inhibitor of TTK, tested alone in solid tumours and with fulvestrant or paclitaxel in breast cancer. Connects to MPS1 (TTK).
1.CFI-402257 slips into a pocket on MPS1 (TTK).
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Query for this drug: (TITLE:"CFI-402257" OR ABSTRACT:"CFI-402257") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CFI-402257, not a curated reading list.
Shares Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer, Treadwell Therapeutics, Breast cancer (all types), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Treadwell Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Treadwell Therapeutics, Breast cancer (all types) and the tag pipeline.
Shares Treadwell Therapeutics, Breast cancer (all types) and the tag pipeline.
Shares Treadwell Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Treadwell Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer, Breast cancer (all types), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Treadwell Therapeutics, Metastatic cancer (cancer that has spread) and the tag pipeline.
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