Loading
CFI-400945 is an experimental small molecule from Treadwell Therapeutics, in phase 2 trials for acute myeloid leukaemia, myelodysplastic syndromes and chronic myelomonocytic leukaemia and other cancers.
CFI-400945 is a small molecule from Treadwell Therapeutics. A small-molecule inhibitor of PLK4, tested alone and with azacitidine or decitabine in myeloid cancers and alone or with durvalumab in breast cancer. Its furthest stage is phase 2, for acute myeloid leukaemia, myelodysplastic syndromes, chronic myelomonocytic leukaemia and breast cancer. ClinicalTrials.gov registers it in 7 studies linked below. NCT04730258 (Treadwell, phase 1/2, AML/MDS/CMML) is active, not recruiting; Canadian Cancer Trials Group phase 2 trials NCT03624543, NCT04176848, NCT03385655 active, not recruiting and NCT05601440 recruiting (registry, checked 3 Nov 2026). Whether it works in people has not been established unless a trial below reports it.
A small-molecule inhibitor of PLK4, tested alone and with azacitidine or decitabine in myeloid cancers and alone or with durvalumab in breast cancer. Connects to PLK4.
1.CFI-400945 slips into a pocket on PLK4.
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Query for this drug: (TITLE:"CFI-400945" OR ABSTRACT:"CFI-400945") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about CFI-400945, not a curated reading list.
Shares Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer, Treadwell Therapeutics, Breast cancer (all types), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Treadwell Therapeutics, Breast cancer (all types), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares PLK4, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Shares Liquid-biopsy Informed Platform Trial to Evaluate CDK4/6-inhibitor Resistant ER+/HER2- Metastatic Breast Cancer, Breast cancer (all types), Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Treadwell Therapeutics, Breast cancer (all types) and the tag pipeline.
Shares Chronic myelomonocytic leukaemia and MDS/MPN overlap neoplasms, Myelodysplastic syndromes / neoplasms (MDS), Acute myeloid leukaemia and the tag pipeline.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/