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DISC-0974 is an experimental monoclonal antibody from Disc Medicine, in phase 2 trials for myelofibrosis and myelodysplastic syndromes.
DISC-0974 is a monoclonal antibody from Disc Medicine, with AbbVie as licensor. An antibody against hemojuvelin that suppresses hepcidin and so increases iron available for making red cells; in oncology it is tested for anaemia caused by myelofibrosis. Its furthest stage is phase 2, for myelofibrosis (anaemia of myelofibrosis) and myelodysplastic syndromes (registry only). ClinicalTrials.gov registers it in one study linked below. RALLY-MF phase 1/2 (NCT05320198) recruiting in myelofibrosis anaemia (registry also lists MDS). Whether it works in people has not been established unless a trial below reports it.
An antibody against hemojuvelin that suppresses hepcidin and so increases iron available for making red cells; in oncology it is tested for anaemia caused by myelofibrosis.
1.DISC-0974 binds its target.
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Query for this drug: (TITLE:"DISC-0974" OR ABSTRACT:"DISC-0974") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about DISC-0974, not a curated reading list.
Shares Disc Medicine and the tag pipeline.
Shares Disc Medicine and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS) and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS) and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS) and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS) and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS) and the tag pipeline.
Shares Myelodysplastic syndromes / neoplasms (MDS) and the tag pipeline.
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