DISC-3405

DISC-3405 (MWTX-003) is a monoclonal antibody from Disc Medicine, with Mabwell as licensor (formerly MWTX-003). An antibody against TMPRSS6 that induces hepcidin and so restricts iron for red-cell production, tested to control red-cell overproduction in polycythaemia vera. Its furthest stage is phase 2, for polycythaemia vera. ClinicalTrials.gov registers it in one study linked below. Phase 2 in PV (NCT06985147) active, not recruiting. Whether it works in people has not been established unless a trial below reports it.