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EPI-326 is an experimental bispecific antibody degrader from EpiBiologics, in phase 1 trials for EGFR-mutant non-small cell lung cancer and head and neck squamous cell carcinoma.
EPI-326 is a bispecific antibody degrader (EpiTAC) from EpiBiologics. A tissue-selective bispecific antibody that degrades both wild-type and mutant EGFR in tumours while sparing EGFR in healthy tissue. Its furthest stage is phase 1, for EGFR-mutant non-small cell lung cancer and head and neck squamous cell carcinoma. ClinicalTrials.gov registers it in one study linked below. Phase 1 NCT07462377 recruiting; first patient dosed per company release of 19 April 2026. Whether it works in people has not been established unless a trial below reports it.
A tissue-selective bispecific antibody that degrades both wild-type and mutant EGFR in tumours while sparing EGFR in healthy tissue. Connects to EGFR.
1.One arm of EPI-326 binds EGFR on the cancer cell.
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Query for this drug: (TITLE:"EPI-326" OR ABSTRACT:"EPI-326") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about EPI-326, not a curated reading list.
Shares Head and neck squamous cell carcinoma, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
Shares EGFR, Non-small-cell lung cancer and the tag pipeline.
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