Eryaspase
Eryaspase packed a leukaemia enzyme into red blood cells to starve pancreatic cancer of an amino acid; the phase 3 TRYbeCA-1 trial missed its survival goal.
Overview
Erytech Pharma, now part of Phaxiam, built eryaspase for tumours that cannot make their own asparagine. A randomised phase 2 in second-line pancreatic cancer had shown longer survival, which led to the phase 3 TRYbeCA-1 trial of eryaspase with chemotherapy against chemotherapy alone in the second line.
TRYbeCA-1 reported in 2021: overall survival was not significantly improved, and the pancreatic programme ended.
Depletes circulating asparagine, an amino acid that pancreatic tumours with low asparagine synthetase cannot make, while the red-cell shell protects the enzyme and reduces toxicity.
1.Eryaspase slips into a pocket on its target.
Trials
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Landmark trials
Latest papers
topQuery for this drug: (TITLE:"Eryaspase" OR ABSTRACT:"Eryaspase" OR TITLE:"GRASPA" OR ABSTRACT:"GRASPA" OR TITLE:"L-asparaginase encapsulated in red blood cells" OR ABSTRACT:"L-asparaginase encapsulated in red blood cells") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Eryaspase, not a curated reading list.