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ETX-929 is an experimental small molecule from Ensem Therapeutics, in phase 1 trials for metastatic colorectal cancer, pancreatic ductal adenocarcinoma and non-squamous non-small cell lung cancer and other cancers.
ETX-929 is a small molecule (oral capsule) from Ensem Therapeutics. An oral pan-KRAS inhibitor that spares HRAS and NRAS and inhibits both the GTP (on) and GDP (off) states, for KRAS-mutant (G12X/G13X/Q61H) and wild-type amplified tumours. Its furthest stage is phase 1, for metastatic colorectal cancer, pancreatic ductal adenocarcinoma, non-squamous non-small cell lung cancer and endometrial adenocarcinoma. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 NCT07912593 (Ensem sponsor), recruiting, actual start 22 Oct 2026, alone and with cetuximab. Whether it works in people has not been established unless a trial below reports it.
An oral pan-KRAS inhibitor that spares HRAS and NRAS and inhibits both the GTP (on) and GDP (off) states, for KRAS-mutant (G12X/G13X/Q61H) and wild-type amplified tumours. Connects to KRAS.
1.ETX-929 slips into a pocket on KRAS.
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Query for this drug: (TITLE:"ETX-929" OR ABSTRACT:"ETX-929") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ETX-929, not a curated reading list.
Shares KRAS, Endometrial cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer and the tag pipeline.
Shares Pancreatic ductal adenocarcinoma, Colorectal cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Endometrial cancer, Ovarian cancer, Colorectal cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Ovarian cancer, Pancreatic ductal adenocarcinoma, Colorectal cancer, Non-small-cell lung cancer and the tag pipeline.
Shares KRAS, Pancreatic ductal adenocarcinoma, Colorectal cancer, Non-small-cell lung cancer and the tag pipeline.
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