Exemestane
Exemestane is a steroidal aromatase inhibitor, the partner of everolimus and the agent tested with ovarian suppression in young women.
Exemestane is an irreversible steroidal aromatase inactivator. It is used after non-steroidal AI failure, with everolimus (BOLERO-2), and with OFS in premenopausal women (TEXT). Generic.
- Route
- Oral
- Schedule
- 25 mg once daily after a meal
- Medicare
- Part D (self-administered)
Oral, self-administered, so it is a Part D drug: covered through a stand-alone Part D plan or Medicare Advantage drug benefit, usually on the specialty tier with 25 to 33% coinsurance until the annual cap ($2,000 in 2025, $2,100 in 2026). Generic.
- Commercial insurance
- covered on label
Multi-source generic on low-cost tiers; usually no prior authorisation. Cash prices without insurance are modest.
Sources: Medicare.gov: Drug coverage (Part D) · Medicare.gov: Costs for Medicare drug coverage (annual out-of-pocket cap). Not medical or financial advice; verify with your plan.
- Notes
- Generic aromatase inhibitor covered by TA112 and NICE NG101; funded routinely.
- NHS England
- Routinely funded for the appraised indication (or via managed access)
Sources: NICE search: exemestane. Funding decisions are indication-specific and change monthly; verify with NICE and your treating team.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1999 | Advanced breast cancer after tamoxifen |
| US | 2005 | Adjuvant after 2-3 years of tamoxifen |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Landmark trials in OnCo
Latest papers
topQuery for this drug: (TITLE:"Exemestane" OR ABSTRACT:"Exemestane" OR TITLE:"Aromasin" OR ABSTRACT:"Aromasin") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Exemestane, not a curated reading list.