termsTerm
Ovarian function suppression (OFS)
Temporarily switching off the ovaries with injections (or removing them) so a premenopausal woman's cancer is starved of oestrogen.
GnRH agonists (goserelin, leuprolide), oophorectomy, or ovarian irradiation. SOFT/TEXT established OFS + aromatase inhibitor for higher-risk premenopausal women; absolute benefit is largest in those under 35 or needing chemotherapy. Required for aromatase inhibitors in premenopausal women, and the likely explanation for chemotherapy's benefit in premenopausal RxPONDER patients.
Clinical: what this kind of term is about · animated schematic, not to scale
Category
Clinical
cancers
1technologies
1drugs
4ApprovedSmall-molecule steroidal aromatase inactivator
Exemestane · Aromasin
ApprovedGnRH agonist
Goserelin / leuprolide (ovarian function suppression) · Zoladex; Lupron
Not mapped hereGnRH agonist depot
Leuprolide (leuprorelin) and GnRH agonists · Lupron / Eligard / Camcevi
ApprovedSmall-molecule SERM
Tamoxifen · Nolvadex