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FMC-376 is an experimental oral covalent small molecule from Frontier Medicines, in phase 1 trials for KRAS G12C-mutated solid tumours and non-small cell lung cancer.
FMC-376 is an oral covalent small molecule from Frontier Medicines. A dual inhibitor that targets both the active (GTP-bound, 'ON') and inactive (GDP-bound, 'OFF') forms of KRAS G12C. Its furthest stage is phase 1, for KRAS G12C-mutated solid tumours and non-small cell lung cancer. ClinicalTrials.gov registers it in one study linked below. Phase 1/2 PROSPER NCT06244771 recruiting. Whether it works in people has not been established unless a trial below reports it.
A dual inhibitor that targets both the active (GTP-bound, 'ON') and inactive (GDP-bound, 'OFF') forms of KRAS G12C. Connects to KRAS.
1.FMC-376 slips into a pocket on KRAS.
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Query for this drug: (TITLE:"FMC-376" OR ABSTRACT:"FMC-376") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about FMC-376, not a curated reading list.
Shares Frontier Medicines, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Frontier Medicines, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares KRAS, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares KRAS, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares KRAS, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares KRAS, Non-small-cell lung cancer and the tag pipeline.
Shares KRAS, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
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