Lenograstim
Lenograstim is Europe's and Japan's glycosylated form of G-CSF, given after chemotherapy to shorten the period of dangerously low neutrophils and to mobilise stem cells for transplant; it does the same job as filgrastim.
Overview
Lenograstim is granulocyte colony-stimulating factor made in Chinese hamster ovary cells, so it carries the sugar chain of the natural protein, unlike filgrastim made in E. coli. It has been approved in Europe and Japan since the early 1990s to reduce the duration of neutropenia after cytotoxic chemotherapy and bone marrow transplantation and to mobilise peripheral blood stem cells in patients and healthy donors. Trials comparing it with filgrastim show equivalent efficacy at comparable doses. It was never approved in the United States.
Activates the G-CSF receptor on neutrophil precursors to drive their proliferation, maturation and release from the marrow. Connects to G-CSF receptor (CSF3R).
1.Lenograstim slips into a pocket on G-CSF receptor (CSF3R).
Trials
topTrials recruiting now
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Latest papers
topQuery for this drug: (TITLE:"Lenograstim" OR ABSTRACT:"Lenograstim" OR TITLE:"Granocyte" OR ABSTRACT:"Granocyte" OR TITLE:"rHuG-CSF glycosylated" OR ABSTRACT:"rHuG-CSF glycosylated") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Lenograstim, not a curated reading list.
Similar pages
not linked directly; found by shared links- TreatmentEflapegrastim
Shares G-CSF receptor (CSF3R), Pegfilgrastim, Cytokines & engineered cytokines and the tag chembl-universe.
- TreatmentSargramostim
Shares Filgrastim (G-CSF), Cytokines & engineered cytokines and the tag chembl-universe.
- TreatmentMotixafortide
Shares Filgrastim (G-CSF) and the tag chembl-universe.
- TreatmentPeginterferon alfa-2b
Shares Cytokines & engineered cytokines and the tag chembl-universe.
- TreatmentOprelvekin
Shares Cytokines & engineered cytokines and the tag chembl-universe.
- CompanySandoz
Shares Pegfilgrastim, Filgrastim (G-CSF).
- TreatmentEfbemalenograstim alfa
Shares Pegfilgrastim, Filgrastim (G-CSF).
- TechnologyGrowth factors: G-CSF and febrile neutropenia prevention
Shares Pegfilgrastim, Filgrastim (G-CSF).