Sargramostim
Sargramostim is a lab-made version of GM-CSF, the signal that tells bone marrow to make white cells; approved in 1991, it shortens the dangerous low-count period after leukaemia chemotherapy and stem cell transplants.
Overview
Sargramostim, recombinant human GM-CSF made in yeast, was approved by the FDA in March 1991 for myeloid reconstitution after autologous bone marrow transplantation in lymphoma and leukaemia. Its label grew to include neutrophil recovery after induction chemotherapy for acute myeloid leukaemia in older adults, stem cell mobilisation, allogeneic transplant and graft failure, and in 2018 the haematopoietic syndrome of acute radiation syndrome. Unlike G-CSF it also stimulates monocytes and dendritic cells, which is why GM-CSF is built into talimogene laherparepvec and several cancer vaccines. Fever, bone pain and fluid retention are the usual side effects.
Activates the GM-CSF receptor on myeloid progenitors, speeding recovery of neutrophils, monocytes and dendritic cells after chemotherapy or transplant. Connects to GM-CSF receptor (CSF2RA).
1.Sargramostim slips into a pocket on GM-CSF receptor (CSF2RA).
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1991 | Myeloid reconstitution after autologous bone marrow transplant; later AML post-induction, stem cell mobilisation, allogeneic transplant, graft failure and acute radiation syndrome |
Trials
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Latest papers
topQuery for this drug: (TITLE:"Sargramostim" OR ABSTRACT:"Sargramostim" OR TITLE:"Leukine" OR ABSTRACT:"Leukine" OR TITLE:"rhu GM-CSF" OR ABSTRACT:"rhu GM-CSF") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Sargramostim, not a curated reading list.
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