GM-CSF receptor (CSF2RA)
The GM-CSF receptor is what sargramostim switches on to speed the recovery of white cells after leukaemia chemotherapy and stem cell transplantation, and it is the signal that tumour vaccines such as talimogene use to recruit immune cells.
Overview
The granulocyte-macrophage colony-stimulating factor receptor is made of a ligand-binding alpha chain (CSF2RA) and the common beta chain shared with the IL-3 and IL-5 receptors. Recombinant GM-CSF (sargramostim, Leukine) is approved to shorten neutrophil recovery after induction chemotherapy for acute myeloid leukaemia and after autologous and allogeneic stem cell transplantation, and to mobilise stem cells. GM-CSF is also encoded into talimogene laherparepvec and several cancer vaccines to attract and mature dendritic cells at the tumour site, while the receptor itself is a marker on juvenile myelomonocytic leukaemia cells.
- Target · the protein and the cell it sits on
- Drug · antibody, small molecule, cell or radioligand
- Effect · signal, damage or kill
In plain words · The GM-CSF receptor is what sargramostim switches on to speed the recovery of white cells after leukaemia chemotherapy and stem cell transplantation, and it is the signal that tumour vaccines such as talimogene use to recruit immune cells.
- 1 · What it is
The GM-CSF receptor is what sargramostim switches on to speed the recovery of white cells after leukaemia chemotherapy and stem cell transplantation, and it is the signal that tumour vaccines such as talimogene use to recruit immune cells.
- 2 · What goes wrong in cancer
A type I cytokine receptor whose beta chain activates JAK2 and STAT5; it drives proliferation and differentiation of granulocyte and macrophage precursors and activates dendritic cells.
- 3 · How drugs use it
No product in this corpus aims at GM-CSF receptor (CSF2RA) yet. Because it sits on the outside of the cell, it can be reached from the bloodstream: antibodies flag the cell, ADCs deliver a toxin, radioligands deliver radiation, and CAR-T or bispecifics bring a T cell.
External identifiers
Biology
A type I cytokine receptor whose beta chain activates JAK2 and STAT5; it drives proliferation and differentiation of granulocyte and macrophage precursors and activates dendritic cells.
- Myeloid progenitors, neutrophils, monocytes and dendritic cells
- Juvenile myelomonocytic leukaemia and some AML blasts
Latest papers
topQuery for this target: (TITLE:"GM-CSF receptor" OR ABSTRACT:"GM-CSF receptor" OR TITLE:"CSF2RA" OR ABSTRACT:"CSF2RA") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about GM-CSF receptor (CSF2RA), not a curated reading list.
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