OnCo
drugsProductPhase 3

177Lu-PSMA-I&T

177Lu-PSMA-I&T is a second PSMA radioligand, chemically different from Pluvicto, that has passed two phase 3 trials on progression but has not yet shown a survival benefit.

SPLASH (Lantheus PNT2002, ESMO 2024): rPFS 9.5 vs 6.0 months (HR 0.71) vs ARPI switch in taxane-naive mCRPC; interim OS HR 1.11 (immature, crossover). ECLIPSE (Curium, 7.4 GBq × 6): met rPFS endpoint vs ARPI in the same setting; OS maturing; FDA submission plan pending. Curium's Japanese registrational trial with PeptiDream started February 2026. Widely used off-protocol in Germany and Australia.

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PSMA-I&T ligand · 2D coordinates (no PubChem conformer)
PubChem
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Radioligand therapy (beta emitters) →
Modality
Radioligand therapy (beta)
Mechanism
Urea-based PSMA ligand with DOTAGA chelator carrying 177Lu; beta emission.
Brand / code
PNT2002 (Lantheus); Curium 177Lu-PSMA-I&T
Where it is approved
USunder reviewEUunder reviewUKJPCNAUcompare regions →

Compare all products across the US, EU, UK, Japan, China and Australia →

Trials

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ClinicalTrials.gov · phase 2/3
refreshed 2026-09-09
14 studies4 recruiting12 Phase 22 Phase 3
Search “177Lu-PSMA-I&T” on ClinicalTrials.gov →
Counts are from a name search and may include unrelated studies; up to 100 studies are summarised.

Recruiting now (live from ClinicalTrials.gov)

Recruiting trials near you · live from ClinicalTrials.gov
177Lu-PSMA-I&T
intervention: 177Lu-PSMA-I&T
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Latest papers

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Literature trend4 papers in the last 12 monthsHow this is computed
Latest papers · live from Europe PMC
Open in Europe PMC

Query for this drug: (TITLE:"177Lu-PSMA-I&T" OR ABSTRACT:"177Lu-PSMA-I&T" OR TITLE:"PNT2002 Lantheus" OR ABSTRACT:"PNT2002 Lantheus" OR TITLE:"Curium 177Lu-PSMA-I&T" OR ABSTRACT:"Curium 177Lu-PSMA-I&T") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about 177Lu-PSMA-I&T, not a curated reading list.

Connected

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Pages like this

not linked directly; found by shared links

cancers

1
Prostate cancer

technologies

2
PSMA PETRadioligand therapy (beta emitters)

targets

1
PSMA

companies

2
CuriumLantheus

trials

2
ECLIPSESPLASH

people

1
Peter Bartenstein