Mechlorethamine (chlormethine)
Mechlorethamine, or nitrogen mustard, was the first chemotherapy ever used, in 1940s Hodgkin lymphoma. Today its main use is as a skin gel (Valchlor in the US, Ledaga in Europe) for early cutaneous T-cell lymphoma.
Overview
Intravenous mechlorethamine (Mustargen, approved 1949) was the M in MOPP, the first curative combination chemotherapy for Hodgkin disease, and was labelled for Hodgkin and non-Hodgkin lymphomas, leukaemias, mycosis fungoides, bronchogenic carcinoma and malignant effusions; the intravenous product has been discontinued in the US. The 0.016% gel (Valchlor) was approved in August 2013 for stage IA and IB mycosis fungoides-type cutaneous T-cell lymphoma after prior skin-directed therapy, on a randomised observer-blinded trial (Study 201) against a compounded ointment; the EU authorised Ledaga in 2017 for the same indication. Contact dermatitis is the main adverse effect of the gel; the intravenous form was a potent vesicant and emetogen.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 1949 | Hodgkin disease and other lymphomas, leukaemias, mycosis fungoides (intravenous; discontinued) |
| US | 2013 | Topical treatment of stage IA and IB mycosis fungoides-type CTCL after skin-directed therapy (Valchlor) |
| EU | 2017 | Topical treatment of mycosis fungoides-type CTCL (Ledaga) |
Trials
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Notes
top- Cutaneous T-cell lymphoma has no cancer record yet.
Latest papers
topQuery for this drug: (TITLE:"Mechlorethamine" OR ABSTRACT:"Mechlorethamine" OR TITLE:"chlormethine" OR ABSTRACT:"chlormethine" OR TITLE:"Mustargen" OR ABSTRACT:"Mustargen" OR TITLE:"historic" OR ABSTRACT:"historic" OR TITLE:"Valchlor gel" OR ABSTRACT:"Valchlor gel" OR TITLE:"Nitrogen mustard" OR ABSTRACT:"Nitrogen mustard") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Mechlorethamine (chlormethine), not a curated reading list.
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