Nelarabine
Nelarabine (Arranon) is an infusion for T-cell acute lymphoblastic leukaemia and lymphoma that has come back after at least two other treatments; it is now also added to first-line therapy for children with T-cell leukaemia.
Overview
Nelarabine received accelerated FDA approval in October 2005 for T-cell acute lymphoblastic leukaemia and T-cell lymphoblastic lymphoma that has not responded to or has relapsed after at least two chemotherapy regimens, on phase 2 studies in adults (complete remission in about a fifth) and children; the EU authorised Atriance in 2007. The Children's Oncology Group AALL0434 trial later showed that adding nelarabine to frontline therapy improved disease-free survival in newly diagnosed T-ALL, and it is now standard in paediatric protocols. Neurotoxicity, including somnolence, peripheral neuropathy and Guillain-Barre-like demyelination, carries a boxed warning.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2005 | Relapsed or refractory T-ALL and T-LBL after at least two regimens (accelerated) |
| EU | 2007 | T-ALL and T-LBL after at least two regimens (Atriance) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
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Latest papers
topQuery for this drug: (TITLE:"Nelarabine" OR ABSTRACT:"Nelarabine" OR TITLE:"Arranon" OR ABSTRACT:"Arranon" OR TITLE:"Atriance" OR ABSTRACT:"Atriance") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Nelarabine, not a curated reading list.
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