Clofarabine
Clofarabine (Clolar) is an infusion for children and young adults whose acute lymphoblastic leukaemia has come back after at least two other treatments.
Overview
Clofarabine is a second-generation purine nucleoside analogue combining features of fludarabine and cladribine. The FDA granted accelerated approval in December 2004 for patients aged 1 to 21 with relapsed or refractory acute lymphoblastic leukaemia after at least two prior regimens, based on a single-arm study in which about 20% of heavily pretreated children achieved complete remission; the EU authorised Evoltra in 2006 for the same paediatric population. It is now used mainly as a bridge to transplant and in combination regimens for relapsed ALL, and off label in adult AML. Capillary leak and systemic inflammatory response syndrome, hepatotoxicity and prolonged cytopenias are the key risks.
Approvals
| Region | Year | Indication |
|---|---|---|
| US | 2004 | Relapsed or refractory ALL in patients aged 1 to 21 after at least two prior regimens (accelerated) |
| EU | 2006 | Relapsed or refractory ALL in children after at least two prior regimens (Evoltra) |
Trials
topRecruiting now (live from ClinicalTrials.gov)
Country and place are remembered in this browser only. A postcode is sent to OpenStreetMap's Nominatim service to find coordinates when you press the button; nothing else leaves your device.
Latest papers
topQuery for this drug: (TITLE:"Clofarabine" OR ABSTRACT:"Clofarabine" OR TITLE:"Clolar" OR ABSTRACT:"Clolar" OR TITLE:"Evoltra" OR ABSTRACT:"Evoltra") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about Clofarabine, not a curated reading list.
Pages like this
not linked directly; found by shared links- ProductNelarabine
Shares Acute lymphoblastic leukaemia, Cytotoxic chemotherapy and the tag nci-list.
- ProductAlemtuzumab
Shares Sanofi and the tag nci-list.
- ProductIxabepilone
Shares Cytotoxic chemotherapy and the tag nci-list.
- ProductRasburicase
Shares Sanofi, Acute lymphoblastic leukaemia and the tag nci-list.
- ProductZiv-aflibercept
Shares Sanofi and the tag nci-list.
- ProductBusulfan
Shares Cytotoxic chemotherapy and the tag nci-list.
- ProductProcarbazine
Shares Cytotoxic chemotherapy and the tag nci-list.
- ProductThiotepa
Shares Cytotoxic chemotherapy and the tag nci-list.