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N17350 is an experimental enzyme therapy: elastase injected into the tumour from Onchilles Pharma, in phase 1 trials for advanced solid tumours, triple-negative breast cancer and cutaneous squamous cell carcinoma and other cancers.
N17350 (NEU-001) is an enzyme therapy: elastase injected into the tumour from Onchilles Pharma. A tumour-directed therapeutic elastase designed to kill cancer cells selectively while preserving immune cells, causing immunogenic cancer cell death that stimulates anti-tumour immunity; the company says it works through the ELANE pathway, which targets altered histone H1 biology. Its furthest stage is phase 1, for advanced solid tumours, triple-negative breast cancer, cutaneous squamous cell carcinoma and melanoma. ClinicalTrials.gov registers it in one study linked below. OP-NEU-101 phase 1/2 (NCT07339176, registry PHASE1/PHASE2, recruiting) enrolling in the US and Australia; first patient dosed announced 4 June 2026. Whether it works in people has not been established unless a trial below reports it.
A tumour-directed therapeutic elastase designed to kill cancer cells selectively while preserving immune cells, causing immunogenic cancer cell death that stimulates anti-tumour immunity; the company says it works through the ELANE pathway, which targets altered histone H1 biology.
1.N17350 binds its target.
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Query for this drug: (TITLE:"N17350" OR ABSTRACT:"N17350" OR TITLE:"NEU-001" OR ABSTRACT:"NEU-001") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about N17350, not a curated reading list.
Shares Onchilles Pharma, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Melanoma, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Non-small-cell lung cancer and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Melanoma, Non-small-cell lung cancer and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Metastatic cancer (cancer that has spread), Non-small-cell lung cancer and the tag pipeline.
Shares Cutaneous squamous cell carcinoma, Head and neck squamous cell carcinoma, Non-small-cell lung cancer and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Melanoma, Non-small-cell lung cancer and the tag pipeline.
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