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SGR-1505 is an experimental small molecule from Schrödinger, in phase 1 trials for relapsed or refractory B-cell malignancies, waldenström macroglobulinaemia and chronic lymphocytic leukaemia and other cancers.
SGR-1505 is a small molecule (oral) from Schrödinger. An inhibitor of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1), which the company describes as a key mediator of the NF-κB signalling pathway and the main driver of a subset of B-cell lymphomas. Its furthest stage is phase 1, for relapsed or refractory B-cell malignancies, waldenström macroglobulinaemia, chronic lymphocytic leukaemia and non-Hodgkin lymphoma. ClinicalTrials.gov registers it in one study linked below. 10-Q for the quarter to 30 June 2026 (filed 5 August 2026): Schrödinger will complete the ongoing phase 1 dose-escalation trial, does not intend to start further trials independently, and plans to seek strategic partners. FDA Fast Track (June 2025) for relapsed/refractory Waldenström macroglobulinaemia after at least two lines including a BTK inhibitor. Whether it works in people has not been established unless a trial below reports it.
An inhibitor of MALT1 (mucosa-associated lymphoid tissue lymphoma translocation protein 1), which the company describes as a key mediator of the NF-κB signalling pathway and the main driver of a subset of B-cell lymphomas. Connects to MALT1.
1.SGR-1505 slips into a pocket on MALT1.
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Query for this drug: (TITLE:"SGR-1505" OR ABSTRACT:"SGR-1505") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about SGR-1505, not a curated reading list.
Shares Schrödinger, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Schrödinger, Metastatic cancer (cancer that has spread) and the tag pipeline.
Shares Waldenström macroglobulinaemia, Chronic lymphocytic leukaemia, Non-Hodgkin lymphoma (all types) and the tag pipeline.
Shares Chronic lymphocytic leukaemia, Non-Hodgkin lymphoma (all types) and the tag pipeline.
Shares Waldenström macroglobulinaemia, Non-Hodgkin lymphoma (all types) and the tag pipeline.
Shares Schrödinger and the tag pipeline.
Shares Chronic lymphocytic leukaemia, Non-Hodgkin lymphoma (all types) and the tag pipeline.
Shares Non-Hodgkin lymphoma (all types), Metastatic cancer (cancer that has spread) and the tag pipeline.
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