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ST-1898 is an experimental small molecule, multi-target tyrosine kinase inhibitor from Beijing Scitech-Mq Pharmaceuticals, in phase 2 trials for unresectable or metastatic melanoma, advanced renal cell carcinoma and radioiodine-refractory differentiated thyroid cancer and other cancers.
ST-1898 (ACC-1898) is a small molecule (oral tablet), multi-target tyrosine kinase inhibitor from Beijing Scitech-Mq Pharmaceuticals, with AccSalus Biosciences as partner. A receptor tyrosine kinase inhibitor with multiple targets, especially VEGFR2, c-MET, AXL, PDGFRA, RET and KIT. Its furthest stage is phase 2, for unresectable or metastatic melanoma, advanced renal cell carcinoma, radioiodine-refractory differentiated thyroid cancer and hepatocellular carcinoma. ClinicalTrials.gov registers it in 4 studies linked below. Phase 2 RAIR-DTC (NCT06359847) and phase 1b/2 melanoma (NCT06359860) recruiting; phase 1b/2 RCC (NCT06127238) active not recruiting; US phase 1 as ACC-1898 (NCT07252661) not yet recruiting. Whether it works in people has not been established unless a trial below reports it.
1.ST-1898 slips into a pocket on MET.
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Query for this drug: (TITLE:"ST-1898" OR ABSTRACT:"ST-1898" OR TITLE:"ACC-1898" OR ABSTRACT:"ACC-1898") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about ST-1898, not a curated reading list.
Shares KIT, RET, MET, Thyroid cancer and the tag pipeline.
Shares Thyroid cancer, Renal cell carcinoma, Hepatocellular carcinoma, Gastric & gastro-oesophageal junction cancer and the tag pipeline.
Shares Renal cell carcinoma, Hepatocellular carcinoma, Gastric & gastro-oesophageal junction cancer and the tag pipeline.
Shares Renal cell carcinoma, Gastric & gastro-oesophageal junction cancer, Melanoma and the tag pipeline.
Shares Renal cell carcinoma, Hepatocellular carcinoma and the tag pipeline.
Shares Hepatocellular carcinoma, Gastric & gastro-oesophageal junction cancer and the tag pipeline.
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