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TS-104 is an experimental peptide-drug conjugate from TwoStep Therapeutics, in phase 1 trials for non-small cell lung cancer, head and neck squamous cell carcinoma and endometrial cancer and other cancers.
TS-104 is a peptide-drug conjugate from TwoStep Therapeutics. A peptide-drug conjugate that links PIP, an engineered knottin peptide binding five tumour-associated integrins, to the cytotoxic payload MMAE, so the drug is carried into cancer cells that carry these integrins. Its furthest stage is phase 1, for non-small cell lung cancer, head and neck squamous cell carcinoma, endometrial cancer and ovarian cancer. ClinicalTrials.gov registers it in one study linked below. FDA IND clearance announced 9 September 2026; first-in-human phase 1 is RECRUITING on the registry. Whether it works in people has not been established unless a trial below reports it.
A peptide-drug conjugate that links PIP, an engineered knottin peptide binding five tumour-associated integrins, to the cytotoxic payload MMAE, so the drug is carried into cancer cells that carry these integrins.
1.TS-104's antibody arm binds its target on the surface of the cancer cell.
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Query for this drug: (TITLE:"TS-104" OR ABSTRACT:"TS-104") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about TS-104, not a curated reading list.
Shares Endometrial cancer, Head and neck squamous cell carcinoma, Ovarian cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Endometrial cancer, Head and neck squamous cell carcinoma, Ovarian cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Oesophageal cancer, Head and neck squamous cell carcinoma, Non-small-cell lung cancer and the tag pipeline.
Shares Oesophageal cancer, Head and neck squamous cell carcinoma, Non-small-cell lung cancer and the tag pipeline.
Shares Oesophageal cancer, Head and neck squamous cell carcinoma, Non-small-cell lung cancer and the tag pipeline.
Shares Endometrial cancer, Head and neck squamous cell carcinoma, Ovarian cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Head and neck squamous cell carcinoma, Ovarian cancer, Non-small-cell lung cancer and the tag pipeline.
Shares Endometrial cancer, Head and neck squamous cell carcinoma, Non-small-cell lung cancer and the tag pipeline.
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