Blunt the inflammation that wakes sleeping cancer cells
Inflammation from infection, injury or surgery can wake dormant cancer cells. Blocking one key inflammatory signal might keep them asleep.
Interleukin-1 beta from the bone marrow niche drives the exit of breast cancer cells from dormancy and metastatic outgrowth in mouse models, and a large cardiovascular trial of canakinumab reported an unexpected reduction in lung cancer incidence and mortality. Later lung cancer treatment trials of canakinumab in advanced disease were negative, which is consistent with awakening being an early, not late, event.
- Dormant cells and minimal residual disease · After a 'successful' treatment, cells can sleep for years then relapse. We can barely detect them and cannot target them.
- Metastasis is understood least and studied last · Metastasis causes about nine in ten cancer deaths but gets a small fraction of research money and almost no trials of its own.
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not linked directly; found by shared links- IdeaKeep dormant cells asleep instead of trying to kill them
Shares Late recurrence, Metastasis is understood least and studied last, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD).
- IdeaFlush dormant cells out of bone marrow, then kill them
Shares Metastasis is understood least and studied last, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- IdeaIntercepting late recurrence with ctDNA surveillance and oral SERDs
Shares Late recurrence, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- IdeaBlock the recycling that keeps dormant cells alive
Shares Late recurrence, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- IdeaUse residual disease tests to decide who needs ten years of hormone therapy
Shares Late recurrence, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.
- IdeaEradicate dormant cancer cells: a programme to wake and kill or lock asleep disseminated cells
Shares Metastasis is understood least and studied last, Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), HR-positive / HER2-negative breast cancer.
- IdeaTake the blood test, and give the drug, at the right time of day
Shares Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing, HR-positive / HER2-negative breast cancer.
- IdeaA dedicated clinic for people whose blood test says the cancer is back
Shares Dormant cells and minimal residual disease, Minimal / molecular residual disease (MRD), MRD / molecular residual disease testing.