Dual-payload ADCs in first line to prevent resistance
Rather than waiting for resistance to one payload and then switching, give two mechanisms from day one, as HIV therapy does.
Combination chemotherapy beats sequential single agents in curable cancers because it prevents selection of resistant clones. Dual-payload ADCs make this possible without doubling antibody dose.
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not linked directly; found by shared links- IdeaAlpha radioligands after ADC failure
Shares Payload-class switching as the rule for ADC sequencing, TROP2, HER2, Antibody-drug conjugate (ADC).
- IdeaCombination baskets defined by resistance mechanism rather than by cancer type
Shares Payload-class switching as the rule for ADC sequencing, Too many combinations to test, Acquired resistance to every therapy, Antibody-drug conjugate (ADC).
- CompanySutro Biopharma
Shares Dual-payload ADC, Site-specific conjugation & linker chemistry, Acquired resistance to every therapy, Antibody-drug conjugate (ADC).
- IdeaRe-map the tumour's surface proteins before choosing the next antibody drug
Shares Payload-class switching as the rule for ADC sequencing, TROP2, Acquired resistance to every therapy, HER2.
- IdeaSequential multiple-assignment randomised trials to find the best order of ADCs
Shares Payload-class switching as the rule for ADC sequencing, Too many combinations to test, Acquired resistance to every therapy, Antibody-drug conjugate (ADC).
- IdeaRotate between drugs on a fixed schedule instead of waiting for failure
Shares Too many combinations to test, Acquired resistance to every therapy, HR-positive / HER2-negative breast cancer.
- ProductARX788
Shares Site-specific conjugation & linker chemistry, HER2, Antibody-drug conjugate (ADC).
- TargetLIV-1 (SLC39A6)
Shares Antibody-drug conjugate (ADC), Triple-negative breast cancer (TNBC), HR-positive / HER2-negative breast cancer.