Alpha radioligands after ADC failure
When ADCs against a surface protein stop working because the payload no longer kills, use the same protein to deliver radiation instead.
Antigen often persists after ADC failure; resistance is at the payload level. A radioconjugate against the same antigen (TROP2, HER2, B7-H3, Nectin-4) would bypass efflux, TOP1 mutations, and SLFN11 loss.
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