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An experimental PET scan from Shanghai that shows TROP2 in breast cancer, and showed that the amount of TROP2 changes with treatment.
[68Ga]Ga-NOTA-T4 was studied at Huashan Hospital, Fudan University, in 42 patients with HER2-negative breast cancer imaged between September 2023 and March 2025 (Liu et al., European Journal of Nuclear Medicine and Molecular Imaging 2026), 27 of whom also had FDG PET. It identified patients and metastatic lesions about as well as FDG. Uptake differed with prior treatment: in luminal B disease, treated patients had higher uptake than untreated ones (maximum standardised uptake value 5.20 against 3.36, p = 0.008), while in triple-negative disease treated patients had lower uptake (3.02 against 7.63, p = 0.008). That is direct imaging evidence that TROP2 expression is not fixed and can move with therapy. A separate registered study at RenJi Hospital, NCT06851663, lists [68Ga]Ga-NOTA-T4 among its tracers.
A TROP2-targeting tracer labelled with gallium-68, imaged by PET to show TROP2 expression across all lesions. Connects to TROP2.
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Query for this drug: (TITLE:"68Ga-NOTA-T4" OR ABSTRACT:"68Ga-NOTA-T4" OR TITLE:"[68Ga]Ga-NOTA-T4" OR ABSTRACT:"[68Ga]Ga-NOTA-T4" OR TITLE:"Gallium-68 NOTA-T4" OR ABSTRACT:"Gallium-68 NOTA-T4") AND (cancer OR tumor OR tumour OR oncology OR carcinoma OR lymphoma OR leukemia OR leukaemia OR myeloma OR sarcoma OR melanoma OR glioma). Results are unfiltered search hits about 68Ga-NOTA-T4, not a curated reading list.
Shares 68Ga-MY6349, TROP2 PET, PET (positron emission tomography), TROP2.
Shares 68Ga-MY6349, PET (positron emission tomography), HR-positive / HER2-negative breast cancer and the tag diagnostic.
Shares 68Ga-MY6349, TROP2 PET, PET (positron emission tomography), TROP2.
Shares PET (positron emission tomography) and the tag frontier.
Shares PET (positron emission tomography) and the tag diagnostic.
Shares Triple-negative breast cancer (TNBC) and the tag frontier.
Shares HR-positive / HER2-negative breast cancer and the tag diagnostic.
Shares TROP2, Triple-negative breast cancer (TNBC) and the tag frontier.
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