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Hartwig Medical Foundation
The Hartwig Medical Foundation sequences the whole genomes of Dutch cancer patients' tumours through participating hospitals and pools the data for research, one of the largest such programmes anywhere.
Overview
Founded in 2015 in Amsterdam, the Hartwig Medical Foundation runs whole-genome sequencing of tumours for patients referred through participating Dutch hospitals and maintains a national database of tumour genomes with clinical data that researchers worldwide can apply to use. Its stated aim is improved cancer patient care driven by data. Access is by referral in the Netherlands.
Location
Amsterdam, NL
Type
consortium
Newsweek 2026 oncology rank
Not in top 300 listing used
OnCo score
#573 · 8 points (0 Newsweek + 0 NCI + 8 from 4 linked objects) · ranking
Key papers
2translationalNature 2019
The Drug Rediscovery Protocol: approved cancer drugs used outside their licence, inside a national trial
It showed that a country can let patients use an approved drug off-label without each case vanishing into an anecdote: every treatment is a trial cohort, and a cohort that works can make the case for paying for that use.
translationalNature 2019
Whole-genome sequencing of 2,520 metastatic tumours from the Dutch Hartwig cohort
This is the cohort behind the Hartwig Medical Database, which the foundation describes as the largest of its kind, offered free of charge to researchers. It showed whole-genome sequencing of metastases done at national scale, and found a variant that could point to a treatment in most of the patients sequenced.
Connected
5Similar pages
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- CompanyProtean BioDiagnostics
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- CompanyCeGaT
Shares Comprehensive genomic profiling and the tag fcct-directory.
- PersonEmile Voest
Shares The Drug Rediscovery Protocol: approved cancer drugs used outside their licence, inside a national trial, DRUP (Drug Rediscovery Protocol).
- IdeaA DRUP-style protocol for off-label generic targeted drugs in rare tumours
Shares DRUP (Drug Rediscovery Protocol), Comprehensive genomic profiling.
- InstitutionNetherlands Cancer Institute (NKI-AvL)
Shares Oncode Institute, The Drug Rediscovery Protocol: approved cancer drugs used outside their licence, inside a national trial, DRUP (Drug Rediscovery Protocol).
technologies
institutions
trials
key papers
Open-source projects
All open source in oncology →Open-source projects that this organisation maintains, from OnCo's own catalogue: licence and last activity as the repository reported them on the day of the fetch. Listing is not endorsement; check the licence before reuse and the validation before clinical use.
- Hartwig hmftools (PURPLE, GRIDSS, LINX, SAGE)GPL-3.0Open code, closed dataAnalysis pipelines & modelling
The Hartwig Medical Foundation's whole-genome cancer analysis suite: purity and ploidy (PURPLE), structural variants (GRIDSS, LINX), point mutations (SAGE) and reporting, run on thousands of Dutch tumours.
Sources
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
hartwigmedicalfoundation.nl · 1
sijbrandijfoundation.org · 1
A source that has moved or gone is reported by the weekly link check. /audit/