Prospective multi-institutional study of adjuvant radiotherapy after resection of borderline and malignant phyllodes tumours
In a prospective study, no woman whose borderline or malignant phyllodes tumour was excised with clear margins and then given radiotherapy had a local recurrence, supporting radiotherapy after breast-conserving surgery for these tumours.
Overview
Prospective study of 46 women with borderline or malignant phyllodes tumours treated with margin-negative breast-conserving resection followed by adjuvant radiotherapy.
With a median follow-up of 56 months there were no local recurrences, compared with historical local recurrence rates of 15 to 30 percent after surgery alone, though distant metastases occurred in a small number of malignant cases.
- Local recurrence 0 percent at a median of 56 months after resection plus radiotherapy.
Adjuvant radiotherapy is considered after breast conservation for borderline and malignant phyllodes tumours; it does not address the risk of distant spread.
- Small, non-randomised study with a historical comparison.