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TALENT screened 12,011 Taiwanese never-smokers aged 55 to 75 with other risk factors by low-dose CT and found lung cancer in 2.6%, most of it stage I; a family history of lung cancer raised the risk. Taiwan's national screening for people with a family history rests on it.
The Taiwan Lung Cancer Screening in Never-Smoker Trial was a nationwide prospective cohort study at 17 tertiary medical centres. Between 1 December 2015 and 31 July 2019 it enrolled 12,011 people aged 55 to 75 (8,868 women) who had never smoked, or had smoked fewer than 10 pack-years and stopped more than 15 years earlier, and had a risk factor: a family history of lung cancer (6,009 people), passive smoking, previous tuberculosis or chronic obstructive lung disease, or heavy or unventilated cooking. This report covers one year after the baseline scan; the study is registered as NCT02611570 and was funded by Taiwan's Ministry of Health and Welfare.
The authors note that in Taiwan lung cancers occur predominantly in never-smokers, nearly 60% of whom have stage IV disease at diagnosis. The Ministry of Health and Welfare cites TALENT as the evidence for including a family history of lung cancer in the national low-dose CT programme that began on 1 July 2022.
Among people who have never smoked, a parent, sibling or child with lung cancer is a strong enough risk factor that Taiwan now screens them, whether or not they smoke.
Shares Low-dose CT lung screening, Lung cancer (all types), Non-small-cell lung cancer.
Shares Low-dose CT lung screening, Lung cancer (all types), Non-small-cell lung cancer.
Shares Low-dose CT lung screening, Lung cancer (all types), Non-small-cell lung cancer.
Shares Low-dose CT lung screening, Non-small-cell lung cancer.
Shares Low-dose CT lung screening, Non-small-cell lung cancer.
Shares Low-dose CT lung screening, Lung cancer (all types), Non-small-cell lung cancer.
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