Loading
The mouse study that started modern FLASH research. Radiation given in a fraction of a second spared the lungs of mice from scarring at doses that scarred them when given at the usual rate, while controlling tumours just as well. It was in mice, and the effect in people has not been shown.
Favaudon and colleagues irradiated mice either with short pulses at 40 Gy per second or more (FLASH) or at the conventional 0.03 Gy per second or less, in single doses. Conventional irradiation at 15 Gy caused lung fibrosis with activation of the TGF-beta cascade, whereas no complications developed after FLASH doses below 20 Gy for more than 36 weeks. FLASH also spared normal smooth muscle and epithelial cells from acute radiation-induced apoptosis. In human tumour xenografts and orthotopic mouse lung tumours, FLASH was as effective as conventional irradiation at repressing tumour growth.
The reason FLASH is being developed. Whether the sparing seen in mice happens in people, at which doses and in which tissues, is the open question that the first human trials have not yet answered.
Shares Science Translational Medicine and the tag precision.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Shares the tags precision, radiation.
Every source this page cites, grouped by who published it. Grouping is read from the web address, not assigned by hand.
A source that has moved or gone is reported by the weekly link check. /audit/