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Delivering an entire dose in under a second, which in animals spares healthy tissue while still killing the tumour.
FLASH radiotherapy delivers the entire dose in milliseconds rather than minutes, at ultra-high dose rates above 40 Gy/s, and in preclinical models this spares normal tissue while killing the tumour equally well. First-in-human trials (FAST-01/02 with protons, Varian; electron trials in Lausanne) show feasibility. The mechanism, proposed as oxygen depletion or radical recombination, is debated, and the clinical effect is unproven. If real, the effect could widen the therapeutic window dramatically, but hardware constraints make it hard to reach deep tumours with current machines. The simple version is that giving radiation in a fraction of a second may protect healthy tissue, and human trials are only now testing whether that holds.
Dose delivered in milliseconds rather than minutes; differential normal-tissue sparing.
Query for this technology: (TITLE:"FLASH radiotherapy" OR ABSTRACT:"FLASH radiotherapy" OR TITLE:"ultra-high dose rate radiotherapy" OR ABSTRACT:"ultra-high dose rate radiotherapy"). Results are unfiltered search hits about FLASH radiotherapy, not a curated reading list.
Shares the tags frontier, precision.
Shares Pencil-beam scanning and intensity-modulated proton therapy, Varian (Siemens Healthineers), Proton therapy machines: cyclotrons, synchrotrons and single-room systems, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag frontier.
Shares A regulatory pathway for new radiotherapy techniques modelled on drug development, A translation fund for academic surgical devices and radiotherapy technology, American Society for Radiation Oncology, Radiotherapy QA phantoms and dosimeters (Sun Nuclear, IBA Dosimetry, PTW) and the tag precision.
Shares Very-high-energy electron therapy, Compact FLASH and proton systems at the price of a conventional linac, A coordinated FLASH radiotherapy evidence programme with shared dose-rate standards, American Society for Radiation Oncology and the tag precision.
Shares A translation fund for academic surgical devices and radiotherapy technology, Surgery and radiotherapy cure most, get least and the tag precision.
Shares A regulatory pathway for new radiotherapy techniques modelled on drug development, Pick the radiation dose that switches the immune alarm on, not off, American Society for Radiation Oncology, Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag precision.
Shares IntraOp Medical, Very-high-energy electron therapy, Jean Bourhis, American Society for Radiation Oncology and the tag precision.
Shares Radiotherapy roadmap: X-rays → shaped beams → fewer fractions, particles and FLASH and the tag frontier.