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In 95,464 nurses followed for 24 years, women who drank two or more sugary drinks a day had double the risk of bowel cancer before 50, and each daily drink in adolescence raised it by a third.
Hur, Otegbeye, Joh and colleagues prospectively investigated the association between sugar-sweetened beverage intake and early-onset colorectal cancer in the Nurses' Health Study II from 1991 to 2015, among 95,464 women who reported adulthood beverage intake on validated food frequency questionnaires every four years. A subset of 41,272 participants reported beverage intake at ages 13 to 18 using a validated high-school questionnaire in 1998. Cox proportional hazards models estimated relative risks.
One hundred and nine cases of early-onset colorectal cancer were documented, which is the number that sets the limits of what the study can claim.
One of the few modifiable exposures with a plausible adolescent window to match the birth-cohort pattern; it is the kind of hypothesis a cohort can generate but not settle.
Shares Gut, Colorectal cancer incidence patterns in the United States, 1974-2013, Geographic and age variations in mutational processes in colorectal cancer, Find out what is driving early-onset bowel cancer, starting with colibactin, before extending screening any further and the tag colorectal-evidence.
Shares Colorectal cancer incidence patterns in the United States, 1974-2013, Find out what is driving early-onset bowel cancer, starting with colibactin, before extending screening any further, Early-onset colorectal cancer (under 50), The hardest cancers are found late and the tag colorectal-evidence.
Shares Colorectal cancer incidence patterns in the United States, 1974-2013, Early-onset colorectal cancer (under 50), The hardest cancers are found late, Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation and the tag colorectal-evidence.
Shares Prevention we already have is not deployed, The hardest cancers are found late, Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation, Colorectal cancer and the tag colorectal-evidence.
Shares Prevention we already have is not deployed, The hardest cancers are found late, Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation, Colorectal cancer and the tag colorectal-evidence.
Shares Prevention we already have is not deployed, The hardest cancers are found late, Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation, Colorectal cancer and the tag colorectal-evidence.
Shares Early-onset colorectal cancer (under 50), Prevention we already have is not deployed, The hardest cancers are found late, Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation and the tag colorectal-evidence.
Shares The hardest cancers are found late, Colorectal cancer roadmap: from the adenoma-carcinoma sequence and the first screening trials to total mesorectal excision, oxaliplatin, RAS testing, immunotherapy for mismatch repair-deficient disease, ctDNA-guided treatment and organ preservation, Colorectal cancer and the tag colorectal-evidence.